Anti-Acetylcholinesterase Activity of Piper sarmentosum by a Continuous Immobilized-enzyme Assay
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چکیده
منابع مشابه
Bioassay-guided isolation of constituents of Piper sarmentosum using a mitochondrial transmembrane potential assay.
Bioassay-guided fractionation was conducted on a chloroform-soluble extract of the aerial parts of Piper sarmentosum collected in Vietnam, monitored by a mitochondrial transmembrane potential assay using HT-29 human colon cancer cells. This led to the isolation of four new C-benzylated dihydroflavones, sarmentosumins A-D (1-4), as well as 14 known compounds. The structures of the new compounds ...
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Phytochemical investigations of Piper sarmentosum Roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, N -(3-phenylpropanoyl) pyrrole and a sterol namely β -sitosterol . 3-(4’-Methoxyphenylpropanoyl) pyrrole was found for the first time in this Piper spe...
متن کاملAnti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase
Biperiden is a drug used in Parkinson disease treatment and it serves also as an antiseizures compound in organophosphates poisoning. It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE) cleaves acetylcholine in synaptic junction into choline and acetic acid. This enzyme is inhibited by various compounds; however there has not been...
متن کاملIn vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum.
ETHNOPHARMACOLOGICAL RELEVANCE Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever. AIM OF THE STUDY In order to establish the pharmacological properties of the leaf of this plant, studies were performed on anti-nociceptive and anti-inflammatory activities. MATERIALS AND METHODS The aqueous extract of ...
متن کاملAntifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum.
Sixty-three amide alkaloids, including three new, piperflaviflorine A (1), piperflaviflorine B (2), and sarmentamide D (4), and two previously synthesized ones, (1E,3S)-1-cinnamoyl-3- hydroxypyrrolidine (3) and N-[7'-(4'-methoxyphenyl)ethyl]-2-methoxybenzamide (5), were isolated from the aerial parts of Piper flaviflorum and Piper sarmentosum. Their structures were elucidated by detailed spectr...
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ژورنال
عنوان ژورنال: APCBEE Procedia
سال: 2012
ISSN: 2212-6708
DOI: 10.1016/j.apcbee.2012.06.035